DSCR1 expression in neurons
It has become evident that various neurological disorders, including intellectual disability, are accompanied by pathological changes in dendritic spines. Recent studies suggest that dysregulation of local protein synthesis in dendritic spines underlies the cellular and molecular bases for dendritic spine abnormalities. We discovered that DSCR1 (Down syndrome critical region1) plays a critical role in regulating dendritic spine morphology and local protein synthesis in dendritic spines.
Axonal growth cones
Axonal growth cones of hippocampal primary neurons from wild type and mutant mice are labelled with antibodies to actin (green) and microtubule (red).
Mitochondria in a mature neuron
Mitochondria are ubiquitous in mammalian cells, providing ATP through aerobic respiration and buffering intracellular calcium. Mitochondria position themselves according to the energy needs of the cell; in this image of mitochondria in a neuron, the organelles are positioned throughout the axon, cell body, and dendrites. Aberrations in this pattern have been previously shown to result in a variety of neurological diseases, such as Parkinson’s Disease.